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Sucralose -- Adverse Effects Seen in Research

Back to the Sucralose (Splenda) Toxicity Information Center

The following adverse effects from sucralose have been reported in research findings:

The manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses. They said that starvation caused the shruken thymus glands. From the New Scientist (23 Nov 1991, pg 13):

Some may ask: “Where can I find published results of the above-reference adverse effects?” These adverse effects where seen in pre-approval research conducted by the manufacturer of sucralose. The number after the adverse effect listed above is the number of the pre-approval study. For obvious reasons, the manufacturer chose to publish only the research that puts sucralose in a good light and not the studies listed above. Some information related to these studies can be found in the FDA Final Rule where the FDA advocates for the manufacturer.

In summary:
So, without even addressing the pre-approval research showing potential toxicity, it is clear that sucralose has a) no long history (e.g., decades) of safe use, b) no independent monitoring of health effects, c) no long-term human studies, and d) no independent human studies. I would hope that the Precautionary Principle, now commonly used in Europe, would be a guiding force for people who are interested in health. Otherwise, we might as well just use any toxic chlorocarbon as a food additive and even go back to using the highly toxic lead acetate as a sugar substitute.

Published research, what little there is, will be discussed in a subsequent article.