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Sucralose -- Adverse Effects Seen in Research
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Sucralose (Splenda) Toxicity Information Center
The following adverse effects from sucralose have been
reported in research findings:
- Shrunken thymus glands (up to 40% shrinkage) (EO56)
- Enlarged liver and kidneys. (EO57 & E161)
- Atrophy of lymph follicles in the spleen and thymus (EO51, EO56, EO151)
- Increased cecal weight (E151)
- Reduced growth rate (EO57)
- Decreased red blood cell count (EO55)
- Hyperplasia of the pelvis (EO57)
- Aborted pregnancy (Maternal & Fetal Toxicity) (E134)
- Decreased fetal body weights and placental weights (EO32)
- Increase glycosylation of hemoglobin (HbA1c) for diabetics (E157)
(Note: One of the effects of increased HbA1c is
The manufacturer claimed that the sucralose was unpleasant for the rodents to
eat in large doses. They said that starvation caused the shruken thymus glands.
From the New Scientist (23 Nov 1991, pg 13):
“[Toxicologist Judith] Bellin reviewed studies on rats starved under
experimental conditions, and concluded that their growth rate could
be reduced by as much as a third without the thymus losing a significant
amount of weight (less than 7 percent). The changes were much more marked
between 7 and 20 percent, their thymuses shrank by as much as 40 percent.”
Some may ask: “Where can I find published results of the above-reference
adverse effects?” These adverse effects where seen in pre-approval research conducted
by the manufacturer of sucralose. The number after the adverse effect listed above
is the number of the pre-approval study. For obvious reasons, the manufacturer chose to
publish only the research that puts sucralose in a good light and not the studies
listed above. Some information related to these studies can be found in the
FDA Final Rule where
the FDA advocates for the manufacturer.
So, without even addressing the pre-approval research showing potential
toxicity, it is clear that sucralose has a) no long history (e.g., decades)
of safe use, b) no independent monitoring of health effects, c) no long-term
human studies, and d) no independent human studies. I would hope that the
Precautionary Principle, now commonly used in Europe, would be a guiding force
for people who are interested in health. Otherwise, we might as well just use any
toxic chlorocarbon as a food additive and even go back to using the highly toxic
lead acetate as a sugar substitute.
- Pre-approval research indicated toxicity of sucralose.
- We can trust the manufacturer to do whatever they can to avoid publishing any
negative information about sucralose in the scientific literature.
- There are no independent controlled human studies on sucralose (similar to 20
years ago for aspartame).
- There are no long-term (12-24 months) human studies of sucralose's effects.
- There is no monitoring of health effects. It took government agencies
decades to agree that there were countless thousands of deaths from
tobacco. Why? Simply because there had been no monitoring or
epidemiological studies. Without such monitoring and studies, numerous serious
adverse effects can easily go unnoticed.
Published research, what little there is, will be discussed in a subsequent article.